Ongoing research concerning the conditions that cause Alzheimer’s led a group of scientists from the Georgetown University Medical Center’s Translational Neurotherapeutics Program to an amazing discovery. Based on the chemical compounds that cause the neuron damage found in the brains of Alzheimer’s patients, researchers learned that the medications formerly approved by the FDA for the treatment of renal cancer prove helpful in combating the disease. Here are what families and Chicago home care providers need to know about the findings.
Alzheimer’s Building Blocks
Tau proteins in the brain assume the responsibility of eliminating harmful amyloid beta proteins. However, in Alzheimer’s and other neurological disorders, tau proteins undergo a transformation process. They convert into a different type of protein that loses the ability to effectively protect neurons. Amyloid proteins are naturally sticky in nature, which enables the molecules to adhere one to another and form clumps. These clumps distort neurons out of alignment, which interferes with the communication between the cells. The accumulation of amyloids also eventually causes cellular destruction.
Scientists learned that enzymes known as tyrosine kinases are the main reason for the abnormal cycle, which causes protein buildup, neurodegeneration and inflammation in the brain. Tyrosine kinase acts as an on/off switch that regulates or interferes with cellular function. The enzyme is also present in malignant cells associated with cancer. The chemotherapy drugs nilotinib and pazopanib are classified as tyrosine kinase inhibitors.
The Georgetown group was determined to learn if the medications might have an effect on the neurodegenerative processes that lead to Alzheimer’s. They administered the medications to laboratory mice exhibiting Alzheimer’s symptoms. After one month, testing the mice revealed that their brains had less abnormal tau proteins, which enabled normal tau to resume the neuroprotective cleaning duties. The group has yet to begin chemotherapy trials on human subjects.
The researchers plan on conducting further studies in order to determine the location of specific receptor sites affected by the medications. In this way, they will better understand how tyrosine kinase forms and releases into the brain.
Living with Alzheimer’s comes with a host of challenges that not every family is prepared to handle alone. Contact Home Care Assistance at (847) 906-3991 today to learn about our comprehensive Chicago Alzheimer’s home care and how it can help your loved one. Our compassionate caregivers help clients with cognitive disorders by stimulating mental function, delaying the onset of dementia, and boosting self-esteem. Schedule a no-obligation consultation today when you call.
(San Francisco, CA—June 1, 2017) Today Home Care Assistance , the leading provider of in-home care for seniors, released a study they commissioned through Research Now illuminating the emotional impact of dementia caregiving in the United States. With one in four adults serving as a caregiver for an aging loved one and with Alzheimer’s and other forms of dementia surging among our rapidly aging population, the unrelenting stress and emotional toll of witnessing the “long goodbye” stands to pose a health care challenge of its own.
With roughly 5.5 million Americans living with dementia, the illness actually costs more to care for ($259 billion) than cancer ($77 billion) and heart disease ($102 billion) combined . Behind these numbers lies a hidden, but very real, emotional cost to family caregivers who help those with Alzheimer’s and other dementias manage daily living.
Based on an analysis of 670 family caregivers in the U.S. surveyed between May 8 and 11 of this year, the following results were concluded:
Dementia caregivers experience higher rates of physical, emotional and mental burnout. Often referred to as “caregiver burnout”, the survey found that dementia caregivers were seven times more likely to experience daily physical, emotional and mental exhaustion from caregiving than non-dementia caregivers. The survey also found that dementia caregivers were three times more likely to feel extreme stress from their caregiving responsibilities than other types of caregivers.
Dementia caregivers feel the most stress from watching their loved one decline, while other caregivers are most stressed from juggling work and care responsibilities. In contrast to other types of care that may have a focus on recovery and rehabilitation, caring for someone with dementia can oftentimes be more challenging since the person is facing a long, inevitable decline. Based on the survey results, 38 percent of those caring for a loved one with dementia feel the most stress from watching their loved one decline, while 33 percent of those caring for a loved one without dementia feel the most stress from having to juggle their job and caregiving responsibilities.
When looking at gender breakdowns of stress, the survey showed that male dementia caregivers were 21 percent more likely to feel stressed from having to juggle their job and caregiving responsibilities than female dementia caregivers.
When it comes to managing child and senior care, female dementia caregivers experience higher rates of caregiver guilt.Numerous studies have shown the disproportionate impact Alzheimer’s and other dementias have on women. Not only do women make up two-thirds of Americans diagnosed with Alzheimer’s , but they also make up two-thirds of the dementia caregiver demographic. Furthermore, researchers at Stanford recently discovered that women are at higher risk “for lowering or exiting their career trajectory owing to caregiver demands.”
According to Home Care Assistance’s survey, female dementia caregivers were twice as likely to feel extreme guilt for not tending to their own family and children’s needs than male dementia caregivers. More so, there were some significant discrepancies seen between females that were caring for a loved one with dementia and females that were caring for a loved one with another disease. Female dementia caregivers were 61 percent more likely to feel extreme guilt for not tending to their own family and children’s needs than non-dementia female caregivers.
“We’re facing an impending health crisis not only for the tens of millions living with Alzheimer’s and other forms of dementia, but also for the loved ones that care for them,” said Lily Sarafan, CEO of Home Care Assistance. “Reliable data on the spectrum of family caregiver experiences, as well as solutions for caregivers to effectively manage their own health and wellness, are essential components of the broader care ecosystem. Our hope is that breathtaking scientific advances and lifespan gains are accompanied by thoughtful leadership and policies to address the realities of caregiving.”
In acknowledgement of the heightened stresses of dementia caregiving, Home Care Assistance will be awarding respite care grants to 60 family caregivers. The program was launched in conjunction with its partnership with Maria Shriver’s Women’s Alzheimer’s Movement and Move for Minds, and is open to caregivers across the country. To learn more or apply for a respite care grant, visit: http://homecareassistance.com/moveforminds .
To view the complete findings around the emotional cost of dementia caregiving, download the full report here: http://homecareassistance.com/emotional-costs-dementia-caregiving .
This survey was conducted online within the United States by Research Now on behalf of Home Care Assistance from May 8th-11th, 2017 among 670 family caregivers aged 18 and older. This online survey is not based on a probability sample and therefore no estimate of theoretical sampling error can be calculated. For complete survey methodology, including weighted variables, contact Grace Zavolock at firstname.lastname@example.org .
About Home Care Assistance
Home Care Assistance is the leading provider of in-home care for seniors serving the United States, Canada and Australia. Its uniquely integrated, science-based approach to aging directly supports individual lifestyles and quality longevity, enabling seniors to live happier, healthier lives at home. Named an Inc. 5000 company eight years in a row and one of the 50 fastest growing women-owned companies worldwide in 2017, Home Care Assistance has been recognized as a 2017 Endorsed National Provider by the home care industry’s leading research firm, Home Care Pulse. Home Care Assistance CEO Lily Sarafan was also named Health Care Executives’ 2016 Woman of the Year. For more information about Home Care Assistance, visit www.homecareassistancecleveland.com .
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Great News!! The Alzheimer’s Association and the Alzheimer’s Impact Movement (AIM) are celebrating the announcement that Congress will pass a $400 million increase for Alzheimer’s research funding at the National Institutes of Health (NIH) in the FY2017 budget. Read the full article: http://www.alz.org/news_and_events_104864.asp?WT.mc_id=enews2017_05_05&utm_source=enews-aff-113&utm_medium=email&utm_campaign=enews-2017-05-05
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I'm participating in the Alzheimer's Association Walk to End Alzheimer's® because I'm committed to raising awareness and funds for Alzheimer's care, support, and research. It is scheduled for October 7, 2017 at the Great Lakes Science Center. More information is coming in the future. I'm leading the way to Alzheimer's first survivor — but I need your help!
Will you help me reach my fundraising goal of $500.00 by making a donation today? Visit my personal fundraising page to make a secure, tax-deductible donation or download and print the paper form on my page to mail in with a check. All donations benefit the Alzheimer's Association — and every dollar makes a difference in this fight.
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